DNA Direct: Your Genes in Context

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Testing for Genetic Disorders

Related Genetic Tests

Cystic Fibrosis

Includes a personalized report, a letter for your doctor, and toll-free support

Price: $260.00

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Pre-test & Post-test Consultation

Our genetic experts can counsel you before and after testing.

Price: $250 per hour

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CYSTIC FIBROSIS

Signs & Symptoms: Cystic Fibrosis

The signs and symptoms of cystic fibrosis can vary greatly. In general, these are the most common features of CF.

Lung Complications
Gastrointestinal Complications
Fertility Issues

Lung Complications

Persistent cough, excessive phlegm
Wheezing, shortness of breath
Frequent lung infections
Chronic bronchiectasis – when the build-up of mucous causes the bronchi (branches in the lungs) to lose elasticity and therefore not function properly.
Chronic sinusitis or asthma (may be caused by mild disease)
Progressive lung deterioration

Gastrointestinal Complications

Poor absorption of nutrients
Large appetite with poor weight gain
Poor growth
Greasy, thick stools
Chronic pancreatitis (inflammation)
Meconium ileus (obstructed intestine in newborns)

Fertility Issues

About 98 percent of men with CF are born with congenital bilateral absence of the vas deferens (CBAVD). CBAVD causes infertility because even though the sperm are present, part of the pathway to release the sperm is missing.
CBAVD can occur in men who do not have a current diagnosis of CF.
- 64 to 72 percent of these men are found to have at least one genetic change in the CFTR gene.
- 19 percent of these men are actually found to have two genetic changes in the CFTR gene.
Women with CF can bear children, but they can experience reduced fertility and pregnancy complications.

These signs and symptoms can vary from person to person in severity, the age when they appear, as well as the extent of treatment required and long-term prognosis.