DNA Direct: Your Genes in Context
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Testing for Genetic Disorders
BREAST & OVARIAN CANCER RISK
Genetics of Hereditary Breast & Ovarian Cancer
Genes run in families. Everyone has two copies of each gene — including the two genes associated with hereditary breast and ovarian cancer. These genes are called BRCA1 and BRCA2.
If someone carries a mutation in one of these genes, there is a 1 in 2 (50 percent) chance that they will pass that mutation on to each child. So knowing your genetic status can be important for your children — as well as other family members.

This table shows the chance that a relative of someone with a mutation for hereditary breast and ovarian cancer has also inherited the gene change.
Relationship to person with mutation |
Chance that they have the mutation |
Chance that they DO NOT have the mutation |
| Identical twin | 100% | 0% |
| Child, Parent, Sibling | 50% | 50% |
| Grandparent, Uncle, Aunt, Niece, Nephew | 25% | 75% |
| First Cousin | 12.5% | 87.5% |
It is important to realize that someone who does not inherit one of these gene changes cannot pass on the genetic risk. However, if someone is found to have one of these changes, other family members can learn more about their individual risk and may choose to have testing.
A HUMAN TOUCH
Our Genetic Experts
Genetic tests personalized to you backed by our expert insights.
Meet Stephen Brown, M.D.
Medical Director
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