DNA Direct: Your Genes in Context

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Testing for Drug Response

Related Genetic Tests

CYP450 Genes

Includes a personalized report, a letter for your doctor, and toll-free support

Price: $250.00 - $630.00

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Pre-test & Post-test Consultation

Our genetic experts can counsel you before and after testing.

Price: $250 per hour

Call to schedule: 1-877-646-0222

Related Genetic Tools

Drug Response Test Finder

Over half of all medications are affected by 3 genes that you can test for: CYP 2D6, 2C9 and 2C19. This tool to see which drugs are affected by these genes.

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THE CYP450 GENES

How Testing Works for Drug Response

DNA Direct's Gene Tests for Drug Response look at three special genes, which are responsible for producing enzymes that your body uses to break-down or "metabolize" medications. People who are "Poor Metabolizers" are more likely to suffer from side effects, receive a potential overdose at the standard dosage, or have a drug not work for them.

DNA Direct offers a three gene drug response panel for $630. Individual gene testing is available for $250-$300.

Which Genes Do You Test?

1. CYP2D6
CYP2D6 affects 25% of drugs in clinical use. About 1 in 10 Caucasians (7-10%) are Poor Metabolizers.
This gene affects: codeine, tamoxifen (Nolvadex), paroxetine (Paxil), amitriptyline (Elavil), atomoxetine (Strattera), tramadol (Ultram), dextromethorphan (Robitussin), propafenone (Rhythmol) and s-metoprolol (Toprol XL). See more

2. CYP2C9
CYP2C9 affects 5-10% of drugs in clinical use. Fewer than 1 in 33 Caucasians (1-3%) are Poor Metabolizers.
This gene affects: warfarin* (Coumadin), phenytoin (Dilantin), glipizide (Glucotrol), ibuprofen (Advil, Motrin) and celecoxib (Celebrex). See more

3. CYP2C19
CYP2C19 affects 15% of drugs in clinical use. Poor Metabolizers are common among Asian populations, where up to 1 in 4 may test positive (13-23%). In Caucasian and African-American populations, up to 1 in 20 are Poor Metabolizers (3-5%).
This gene affects: omeprazole (Prilosec), diazepam (Valium and other brands) and phenytoin (Dilantin). See more

* Testing for warfarin response requires analysis of 2 genes: CYP2C9 and VKORC1. Learn more about Warfarin Response Testing.