Who Should Test?
Medical Guidelines and References
How to Order Testing For Your Patient
Who Should Test?
Hallmark features in a personal and family history that suggest hereditary breast and ovarian cancer are:
- Breast cancer before age 50
- Ovarian cancer at any age
- Bilateral breast cancer, multiple primaries in one breast
- Breast and ovarian cancer in the same person
- Male breast cancer
- Breast and/or ovarian cancer in multiple generations
- Ashkenazi Jewish ancestry
Medical Guidelines and References
Guidelines:American College of Medical Genetics Foundation. 1999. Genetic susceptibility to breast and ovarian cancer: assessment, counseling and testing guidelines. Genetics in Medicine.
American College of Medical Genetics. 1996. BRCA-1 Mutation in Ashkenazi Jewish Women, Statement on Population Screening. ACMG Newsletter 7:9.
American Society of Clinical Oncology policy statement update: Genetic testing for cancer susceptibility. 2003. J Clin Oncol. Jun 15;21(12):2397-406.
Nelson HD, Huffman LH, Fu R, Harris EL; U.S. Preventive Services Task Force. 2005. Genetic risk assessment and BRCA mutation testing for breast and ovarian cancer susceptibility: Systematic evidence review for the U.S. Preventive Services Task Force. Ann Intern Med. 143(5):362-79.
Smith, T. J. et al. 1999. American Society of Clinical Oncology 1998 Update of Recommended Breast Cancer Surveillance Guidelines. Jnl Clin Onc. 17(3): 1080-1082.
Trepanier, A. et al. 2004. Genetic cancer risk assessment and counseling: recommendations of the national society of genetic counselors. Jnl Gen Counsel. 13(2) 83-112.
UK Cancer Family Study Group (UKCFSG). 2000. Guidelines for a genetic risk based approach to advising women with a family history of breast cancer. J Med Genet. Mar;37(3):203-9.
Key References:
Hampel, H. et al. 2004. Referral for cancer genetics consultation: a review and compilation of risk assessment criteria. J Med Genet 41(2): 81-91.
American Cancer Society guidelines for breast cancer screening: update 2003. CA Cancer J Clin 53(3):141-69.
http://www.guideline.gov/summary/summary.aspx?
ss=15&doc_id=3745&nbr=2971
American Society of Breast Disease. 2004. The use of magnetic resonance imaging of the breast (MRIB) for screening of women at high risk of breast cancer. Dallas (TX): American Society of Breast Disease; Jun 28.
http://www.guideline.gov/summary/summary.aspx?
ss=15&doc_id=5418&nbr=3715
Bohm-Velez, M. et al. 2005. Expert Panel on Women's Imaging. Ovarian cancer screening. [online publication]. Reston (VA): American College of Radiology (ACR).
http://www.guideline.gov/summary/summary.aspx?
ss=15&doc_id=8319&nbr=4651
How to Order Testing For Your Patient
Ordering testing for your patient through DNA Direct is easy.
- Print and complete the DNA Direct Referral Form, and fax it to 806-993-6708, Attention: Clinical Services. (Make sure your patient signs the form and checks the box authorizing DNA Direct to release test results to you.)
- DNA Direct will send a blood sample collection kit directly to your patient and will coordinate all testing services. As part of the testing process, your patient is asked to create a user account with DNA Direct and answer a brief clinical questionnaire.
- Your patient will use the voucher included in the testing kit for a blood draw at a local LabCorp patient service center. LabCorp will send the sample directly to the testing lab.
- When testing is complete, as the referring physician you receive a copy of the test results and a Physician Letter, complete with test result interpretation, current medical guidelines, and scientific references. Your patient can then log on to their secure, password-protected account to learn more about their test results and receive updates on clinically relevant information.
- You and your patients have ongoing access to support services from DNA Direct's board-certified genetics staff by phone (toll-free at 1-877-646-0222, M-F, 9-5 Pacific) and email (expert@dnadirect.com).
